Downstream process designBuilt for biotech engineers

Separate
the broth.
Rank the
routes.

Define a feed. The generator lays out every viable downstream train and ranks them by yield, purity and cost, streaming results as it finds them.

Try it free → no install · runs in the browser
34
unit operations
Any
molecule you can run
10k+
routes per run
Fig. 1 — Lysozyme · fermentation broth separating
Route
#12 / 8,412
Yield
100.0%
Purity
14.0%
CAPEX
$12.3M
Fig. 2 — Generated route · Lysozyme DSP route #12 / 8,412
Yield87.4%
Purity96.2%
CAPEX$12.3M
Feed
Lysozyme · HCP
salts · debris
120 L/hr
Centrifuge
UF 10k
IEX
Spray dry
Lysozyme
Waste
Waste
01
Route generation

Thousands of processes, ranked

A diversity-preserving genetic search proposes downstream trains; a rules engine drops the ones that would never run in a plant.

Ranked, not just generated

Every candidate scored on recovery, purity and installed cost. Sort or filter on any of them.

  • Genetic search tuned for breadth over one optimum
  • 33 engineering constraints reject infeasible trains
  • Filter by selectivity, concentration or economics
  • Streaming output, routes land as found
01Centrifuge → UF 10k → IEX → Spray dry94
02Disc centrifuge → MF → Affinity → Freeze dry88
03Depth filter → UF 30k → SEC → Spray dry82
04Centrifuge → NF → IEX → Vacuum tray77
05Microfiltration → UF 10k → RP-HPLC71
02
Techno-economics

A price tag on every option

Power-law scaling from real equipment data, Lang factors for installation, utilities and labor read straight off the flowsheet.

Price it before you build it

CAPEX · one-time
Equipment purchase$7,020,000
Installation (Lang factor)$5,280,000
Total CAPEX$12,300,000
OPEX · per year
Utilities$1,040,000
Labor$720,000
Total OPEX / yr$1,760,000
Illustrative summary · not the full model

Compare the trade-off

Every route carries CAPEX, OPEX and utilities, auto-sized to your throughput. See the whole set in yield × purity × cost space.

  • 37 operations with industry cost curves
  • Per-operation scaling exponents (0.5–0.75)
  • Auto-sized to your production rate
  • 3D trade-off plot across all results
03
The workspace

Everything in one place

A

Any molecule

300+ curated molecules with full properties (MW, pKa, solubility, pI, diffusion), or define your own. Run essentially anything.

B

Live mass balance

Stream-level concentrations, flow and pH update as you build the train.

C

Multi-product trains

Co-purify several targets with branching outlets and per-product yields.

D

Expert rules

33 constraints block infeasible designs: chromatography prereqs, fouling, drying order.

E

3D trade-off plot

Every route in yield × purity × CAPEX space. Pick the corner you want to live in.

04
The method

Three moves

1

Define the feed

Flow, pH and components. Pick from the library or enter a custom molecule.

2

Generate routes

Set yield and purity targets, then explore thousands of downstream sequences.

3

Pick and export

Compare by yield, purity and CAPEX. Drop the winner onto the canvas.

Point it at your
hardest separation.

no install · no spreadsheets · runs in the browser

Open the app →