Build smarter
purification routes, faster

Downstream bioprocess design for biotech engineers — define your feed, explore thousands of separation routes, and compare by yield, purity, and cost.

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34+ unit operations
200+ molecule database
10,000+ routes explored
ProcessDesign — Lysozyme DSP Route · Route #12 · Feasibility 94%
87.4% Yield
96.2% Purity
$1.2M CAPEX
Feed
Centrifuge
UF 10k
IEX
Spray Dry
Product
Waste
Waste
120 L/hr 98 L/hr 82 L/hr 75 L/hr 68 L/hr

Every route explored and ranked

Genetic algorithm ranks every route by yield, purity, and cost. Expert rules ensure feasibility. Results stream in real-time.

  • Diversity-preserving genetic algorithm
  • Expert engineering constraints built-in
  • Filter by selectivity, concentration, or economics
  • Streaming results — watch routes appear live
📈 Top Routes — Balanced (50 shown)
1
Centrifuge → UF 10k → IEX → Spray Dry
94%
2
Disc Centrifuge → MF → Affinity → Freeze Dry
88%
3
Depth Filter → UF 30k → SEC → Spray Dry
82%
4
Centrifuge → NF → IEX → Vacuum Tray
77%
5
Microfiltration → UF 10k → RP-HPLC
71%
Techno-Economic Analysis

Every route has a price tag

Auto-scaled cost estimation. Compare CAPEX, OPEX, and utilities across all routes. See the trade-offs in 3D space.

  • 37 operations with industry cost data
  • Per-operation power-law scaling (0.5–0.75 exponents)
  • Lang factors for installation
  • 3D plot: yield × purity × CAPEX
💰 Cost Breakdown — Route #12
Purchase
$862k
Install
$658k
Utilities
$104k/yr
Labor
$72k/yr
Total CAPEX
$1.52M
Scale: 100 L/hr ✓ Feasible route

Everything in one workspace

Feed definition to cost analysis. No spreadsheets, no external tools.

Molecule Database

200+ molecules with MW, pKa, solubility, pI, diffusion coefficients.

Real-Time Simulation

Stream-level mass balances. Concentrations, flow, pH — live updates.

Multi-Product Routes

Co-purify multiple targets. Branching outlets. Per-product yields.

pH Tracking

Full propagation through mixing and reagents. Precipitation warnings.

Expert Rules

33 constraints block infeasible designs. Chromatography prereqs, fouling limits, distillation rules.

3D Visualization

Plot all routes in yield × purity × CAPEX space. Pick your trade-off.

How it works

Feed → Routes → Analysis

Three steps. One workspace. Zero spreadsheets.

1

Define feed

Flow rate, pH, components. Pick from 200+ molecules or enter custom.

2

Generate routes

Explore 10,000+ sequences. Set yield and purity targets.

3

Select best

Compare by yield, purity, CAPEX. Export your design.

Get started

Start designing now

No installation. No spreadsheets. Just engineering.

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